These are The Official UK Charts Company UK Official Dance Chart number one hits of 2000.
| Issue date | Song | Artist |
|---|---|---|
| 1 January | "A Little Bit Of Luck" | DJ Luck & MC Neat |
| 8 January | "A Little Bit Of Luck" | DJ Luck & MC Neat |
| 15 January | "A Little Bit Of Luck" | DJ Luck & MC Neat |
| 22 January | "Rise" | Eddie Amador |
| 29 January | "Pitchin' (In Every Direction)" | Hi-Gate |
| 5 February | "Hear You Calling" | Aurora |
| 12 February | "Breathe And Stop" | Q-Tip |
| 19 February | "Must Be The Music" | Joey Negro feat Taka Boom |
| 26 February | "I'm in Love (Starparty song)" | Starparty |
| 4 March | "Movin' Too Fast" | Artful Dodger & Romina Johnson |
| 11 March | "Movin' Too Fast" | Artful Dodger & Romina Johnson |
| 18 March | "Stop Playing With My Mind" | Barbara Tucker |
| 25 March | "Stop Playing With My Mind" | Barbara Tucker |
| 1 April | "Right Before My Eyes" | N'n'G feat Kallaghan |
| 8 April | "Right Before My Eyes" | N'n'G feat Kallaghan |
| 15 April | "Flowers" | Sweet Female Attitude |
| 22 April | "Toca's Miracle" | Fragma |
| 29 April | "Imagine" | Shola Ama |
| 6 May | "Crazy Love" | MJ Cole |
| 13 May | "Heart Of Asia" | Watergate |
| 20 May | "Tell Me Why (The Riddle)" | Paul Van Dyk feat Saint Etienne |
| 27 May | "Masterblaster" | DJ Luck & MC Neat |
| 3 June | "It Feels So Good" | Sonique |
| 10 June | "On the Beach" | York |
| 17 June | "Girls Like Us" | B15 feat Chrissy D and Lady G |
| 24 June | "Sandstorm" | Darude |
| 1 July | "The Power of Love" | Frankie Goes to Hollywood |
| 8 July | "Voices" | Bedrock |
| 15 July | "Beautiful" | Matt Darey's Mash Up presents Marcella Woods |
| 22 July | "I Need Your Lovin (Like the Sunshine)" | Marc Et Claude |
| 29 July | "Sing A Long" | Shanks & Bigfoot |
| 5 August | "Fly Bi" | Teebone feat MC Kie & MC Sparks |
| 12 August | "Time to Burn" | Storm |
| 19 August | "I Feel for You" | Bob Sinclar |
| 26 August | "Groovejet (If This Ain't Love)" | Spiller |
| 2 September | "Groovejet (If This Ain't Love)" | Spiller |
| 9 September | "Freak Like Me" | Tru Faith & Dub Conspiracy |
| 16 September | "Lady (Hear Me Tonight)" | Modjo |
| 23 September | "Scorchio" | Sasha/Emerson |
| 30 September | "Kernkraft 400" | Zombie Nation |
| 7 October | "Sorry (I Don't Know)" | Monsta Boy feat Denzie |
| 14 October | "Silence (Remixes)" | Delerium feat Sarah McLachlan |
| 21 October | "Doom's Night" | Azzido Da Bass |
| 28 October | "Pasilda" | Afro Medusa |
| 4 November | "Gettin' in the Way" | Jill Scott |
| 11 November | "Greed/The Man with the Red Face" | Laurent Garnier |
| 18 November | "138 Trek" | DJ Zinc |
| 25 November | "One More Time" | Daft Punk |
| 2 December | "Operation Blade (Bass in the Place)" | Public Domain |
| 9 December | "Phatt Bass" | Warp Brothers vs Aquagen |
| 16 December | "Dedicated to Love" | Marissa |
| 23 December | "Storm Animal" | Storm |
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